Welcome to the web site of the Experimental Bioinformatics chair at the Technical University of Munich headed by Prof. Dr. Jan Baumbach

We are a research laboratory that investigates the molecular mechanisms driving complex diseases using artificial intelligence methodology and combinatorial optimization.

We develop computational methods for Systems and Network Medicine, in particular for de novo endophenotyping, mechanotyping and redefinition of diseases by classifying their mechanistic causes rather than relying on symptoms. Here, we emerge novel ways for drug repurposing and synergistic pharmacology.

We also develop privacy-preserving artificial intelligence tools to unleash the power of big data in precision medicine, where sensitive data may not be shared cross-institutionally for model learning. We thus develop privacy-by-design methods for federated AI model learning that respect differential privacy. 

 

Chair of Experimental Bioinformatics

TUM School of Life Sciences Weihenstephan

Technical University of Munich

Tel: +49-8161-71-2136

E-Mail: exbio[a.t_))wzw.tum.de

Office: OG-L06

Synergistic pharmacology

Together with Prof. Harald Schmidt from UMaastricht and his lab, we show that combining a NOS and a NOX inhibitor at subthreshold concentrations emerge pharmacologic synergy, as evidenced by reduced cell death and infarct size, stabilized blood–brain barrier, reduced reoxygenation-induced leakage, and preserved neuromotor function.

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